deconvolveR is a package for Empirical Bayes Deconvolution and Estimation. A friendly introduction is provided in the JSS paper reference below and this package includes a vignette containing a number of examples.

References

Bradley Efron. Empirical Bayes Deconvolution Estimates. Biometrika 103(1), 1-20, ISSN 0006-3444. doi:10.1093/biomet/asv068. http://biomet.oxfordjournals.org/content/103/1/1.full.pdf+html

Bradley Efron and Trevor Hastie. Computer Age Statistical Inference. Cambridge University Press. ISBN 978-1-1-7-14989-2. Chapter 21.

Balasubramanian Narasimhan and Bradley Efron. deconvolveR: A G-Modeling Program for Deconvolution and Empirical Bayes Estimation. doi:10.18637/jss.v094.i11